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Avoid therapy in sufferers with head injury, intracranial lesions, or perhaps a pre-existing boost in intracranial pressure; in people who may very well be liable to intracranial outcomes of CO2 retention could reduce respiratory generate, and resultant CO2 retention can additional improve intracranial tension; opioids also produce adverse reactions that may obscure clinical class of patients with head injuries

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fentanyl transdermal and codeine each boost sedation. Stay away from or Use Alternate Drug. Limit use to patients for whom alternate procedure solutions are inadequate

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Drugs that have quantity boundaries associated with Every single prescription. This restriction normally limits the quantity in the drug that may be protected.

Dosage really should not be increased if cough fails to respond; an unresponsive cough really should be reevaluated in 5 days or sooner for attainable fundamental pathology, such as foreign human body or decreased get more info respiratory tract sickness

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